Stopping the Clock on Seizures!

Xiaoqin Fu; Judy S Liu; Peijun Li

doi:10.1016/j.tins.2021.04.002

Stopping the Clock on Seizures!

Trends Neurosci. 2021 Jun;44(6):422-423. doi: 10.1016/j.tins.2021.04.002. Epub 2021 May 6.

Authors

Xiaoqin Fu¹, Judy S Liu², Peijun Li³

Affiliations

¹ The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
² Department of Neurology, Brown University, Providence, RI 02903, USA; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA. Electronic address: judy_liu@brown.edu.
³ The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. Electronic address: 218004@wzhealth.com.

PMID: 33965214
DOI: 10.1016/j.tins.2021.04.002

Abstract

A recent paper by Zhang et al. shows that REV-ERBα, a negative regulator of the circadian molecular clock, is pro-convulsant through its action on GABA signaling. The findings support the role of the circadian molecular clock in epilepsy and suggest REV-ERBα as a potential therapeutic target for the management of seizures.

Keywords: circadian molecular clock; epilepsy; tonic GABA.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Circadian Clocks*
Circadian Rhythm
Humans
Nuclear Receptor Subfamily 1, Group D, Member 1* / metabolism
Seizures
Signal Transduction

Substances

Nuclear Receptor Subfamily 1, Group D, Member 1

Grants and funding

R01 NS104428/NS/NINDS NIH HHS/United States