The Technetium Articular Index (TcAI) is regarded as a parameter of local inflammation in rheumatoid arthritis (RA). We studied TcAI behaviour during 1-year chrysotherapy in a group of fifteen RA patients. In non-responders TcAI showed a gradual decrease up to the 6th month and a return to baseline values within the second semester of the follow-up; conversely, in response patients TcAI remained unchanged during the entire period of the study, thus showing a paradoxical behaviour probably depending on the recovery of normal physical ability and articular activity.