ecDNA party bus: Bringing the enhancer to you

Karen Adelman; Benjamin J E Martin

doi:10.1016/j.molcel.2021.04.017

ecDNA party bus: Bringing the enhancer to you

Mol Cell. 2021 May 6;81(9):1866-1867. doi: 10.1016/j.molcel.2021.04.017.

Authors

Karen Adelman¹, Benjamin J E Martin²

Affiliations

¹ Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: karen_adelman@hms.harvard.edu.
² Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.

PMID: 33961776
DOI: 10.1016/j.molcel.2021.04.017

Abstract

Recent work from Zhu et al. (2021) reveals that extrachromosomal DNA circles harboring enhancers can serve as mobile regulatory elements that interact with chromosomal oncogenes, stimulating high-level gene activity and contributing to tumor heterogeneity and cancer progression.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Carcinogenesis
Chromosomes
Humans
Neoplasms* / genetics
Oncogenes*
Regulatory Sequences, Nucleic Acid

Abstract

Publication types

MeSH terms

Grants and funding