Glimpses into evolutionary trajectories of SARS-CoV-2: emerging variants and potential immune evasion routes

Cleo Anastassopoulou; Yiannis Manoussopoulos; Vicky Lampropoulou; Athanasios Tsakris

doi:10.2217/fmb-2020-0300

Glimpses into evolutionary trajectories of SARS-CoV-2: emerging variants and potential immune evasion routes

Future Microbiol. 2021 May:16:455-459. doi: 10.2217/fmb-2020-0300. Epub 2021 May 7.

Authors

Cleo Anastassopoulou¹, Yiannis Manoussopoulos^{1

2}, Vicky Lampropoulou³, Athanasios Tsakris¹

Affiliations

¹ Department of Microbiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
² Laboratory of Virology, Plant Protection Division of Patras, ELGO-Demeter, Patras, Greece.
³ Laboratory of Immunobiology, Center for Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation of The Academy of Athens, Athens, Greece.

Abstract

Tweetable abstract An opinion on the coronaviruses' evolution paradoxes, the continuing adaptation of the SARS-CoV-2 in humans following the zoonotic transmission, and clues into escape routes from host immune responses.

Keywords: APOBEC; COVID-19; SARS-CoV-2 variants of concern; adaptation; coronavirus; genetic diversity; genome evolution; immune escape; spike; vaccines.

Publication types

Editorial

MeSH terms

COVID-19 / immunology
COVID-19 / virology
Evolution, Molecular*
Genome, Viral
Humans
Immune Evasion*
SARS-CoV-2 / genetics*