Outcomes of post-chemotherapy robot-assisted retroperitoneal lymph node dissection in testicular cancer: multi-institutional study

World J Urol. 2021 Oct;39(10):3833-3838. doi: 10.1007/s00345-021-03712-7. Epub 2021 May 7.

Abstract

Objective: To evaluate the perioperative and oncological outcomes after post-chemotherapy robot-assisted retroperitoneal lymph node dissection (PC-RARPLND).

Materials and methods: We retrospectively reported the perioperative and oncological outcomes of all the patients with testicular cancer who underwent PC-RARPLND at three tertiary teaching centers. Descriptive statistical measures were used to report demographic, clinical, intraoperative, postoperative and oncological outcomes.

Results: There were 43 consecutive patients who underwent PC-RARPLND at the participating institutions. Mean patient age was 29.2 years (± 8.2), BMI was 26.6 kg/m2 (± 6.2). The mean size of retroperitoneal mass was 4.1 cm (± 3.5). Full bilateral template dissection was performed in 38 (88.3%) patients. Nerve sparing was attempted in 19 (44.1%) patients. Mean operative time was 374 min (± 132) and estimated blood loss was 292 ml (± 445.6). The mean postoperative LOS was 2.8 days (± 5.9). There was a total of 12 complications in 10 patients (Clavien grade I = 5, II = 3, III = 3 and IV = 1). Postoperative pathology demonstrated 24 patients (55%) with necrosis/fibrosis, 16 (37%) with teratoma and 3 (7%) with viable tumor. Mean lymph node (LN) yield was 26.5 LNs (SD ± 16.1). Patients were followed for a mean of 30.7 months (± 24.7). No deaths were documented during follow-up and 2 pulmonary recurrences were identified. Antegrade ejaculation was preserved in 70.6% of patient who underwent nerve sparing. Limitations included retrospective nature and limited follow up.

Conclusion: PC-RAPLND is safe and technically reproducible. It provides improved morbidity and less convalescence.

Keywords: Retroperitoneal lymph node dissection; Robotic retroperitoneal lymph node dissection; Testis cancer.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Carcinoma, Embryonal / drug therapy
  • Carcinoma, Embryonal / pathology
  • Carcinoma, Embryonal / surgery
  • Ejaculation
  • Endodermal Sinus Tumor / drug therapy
  • Endodermal Sinus Tumor / pathology
  • Endodermal Sinus Tumor / surgery
  • Humans
  • Induction Chemotherapy
  • Lymph Node Excision / methods*
  • Male
  • Neoplasm Staging
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Neoplasms, Germ Cell and Embryonal / pathology
  • Neoplasms, Germ Cell and Embryonal / surgery*
  • Orchiectomy
  • Organ Sparing Treatments
  • Postoperative Complications / epidemiology*
  • Retroperitoneal Space / surgery*
  • Retrospective Studies
  • Robotic Surgical Procedures / methods*
  • Seminoma / drug therapy
  • Seminoma / pathology
  • Seminoma / surgery
  • Sexual Dysfunction, Physiological / epidemiology*
  • Teratoma / drug therapy
  • Teratoma / pathology
  • Teratoma / surgery
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / pathology
  • Testicular Neoplasms / surgery*
  • Young Adult