Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses

Janardhan Avilala; David Becnel; Ramsy Abdelghani; Asuka Nanbo; Jacob Kahn; Li Li; Zhen Lin

doi:10.3389/fmicb.2021.657036

Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses

Front Microbiol. 2021 Apr 20:12:657036. doi: 10.3389/fmicb.2021.657036. eCollection 2021.

Authors

Janardhan Avilala¹, David Becnel², Ramsy Abdelghani², Asuka Nanbo³, Jacob Kahn¹, Li Li⁴, Zhen Lin¹

Affiliations

¹ Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA, United States.
² Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States.
³ National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan.
⁴ Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA, United States.

Abstract

Human oncogenic viruses are a group of important pathogens that etiologically contribute to at least 12% of total cancer cases in the world. As an emerging class of non-linear regulatory RNA molecules, circular RNAs (circRNAs) have gained increasing attention as a crucial player in the regulation of signaling pathways involved in viral infection and oncogenesis. With the assistance of current circRNA enrichment and detection technologies, numerous novel virally-encoded circRNAs (vcircRNAs) have been identified in the human oncogenic viruses, initiating an exciting new era of vcircRNA research. In this review, we discuss the current understanding of the roles of vcircRNAs in the respective viral infection cycles and in virus-associated pathogenesis.

Keywords: EBV; HBV; HPV; KSHV; MCV; circRNA; circular RNA; oncogenic virus.

Publication types

Review

Abstract

Publication types

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