Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study

Abstract

Background: Additional study is warranted to investigate the causal effects between kidney function and obstructive lung disease.

Methods: This study was a bidirectional two-sample Mendelian randomisation (MR) analysis. The Chronic Kidney Disease Genetics (CKDGen) genome-wide association study (GWAS) meta-analysis for estimated glomerular filtration rate (eGFR) including individuals of European ancestry (n=567 460) provided the genetic instrument for kidney function and outcome summary statistics. A GWAS for forced expiratory volume in 1 s (FEV₁)/forced vital capacity (FVC) including individuals of European ancestry from the UK Biobank (n=321 047) provided the genetic instrument for FEV₁/FVC and outcome data. A polygenic score (PGS) analysis was performed to test the causal estimates from kidney function to binary obstructive lung disease outcomes, including COPD, asthma and FEV₁/FVC <70%, and to perform nonlinear MR with individual-level UK Biobank data.

Results: The causal estimates by summary-level MR indicated that genetically predicted increased kidney function was significantly associated with increased FEV₁/FVC z-scores (10% increase in eGFR; β=0.055, 95% CI 0.024-0.086). The PGS for increased eGFR showed a significant association with a reduced risk of FEV₁/FVC <70% (OR 0.93, 95% CI 0.87-0.99), COPD (OR 0.93, 95% CI 0.87-0.99) and late-onset (age ≥50 years) asthma (OR 0.93, 95% CI 0.88-0.99). The nonlinear MR demonstrated that the causal effect from eGFR to FEV₁/FVC was apparent in eGFR ranges <60 mL·min^-1·1.73 m^-2. Conversely, genetically predicted FEV₁/FVC showed nonsignificant causal estimates of eGFR change (β=0.568%, 95% CI -0.458-1.605%).

Conclusion: This study supports kidney function impairment as a causative factor for obstructive lung disease.