Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity

Khamidulla Kamoldinov; Jun Li; Komila Eshbakova; Shamansur Sagdullaev; Gaoya Xu; Yubo Zhou; Jia Li; Haji Akber Aisa

doi:10.1016/j.phytochem.2021.112705

Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity

Phytochemistry. 2021 Jul:187:112705. doi: 10.1016/j.phytochem.2021.112705. Epub 2021 May 3.

Authors

Khamidulla Kamoldinov¹, Jun Li¹, Komila Eshbakova², Shamansur Sagdullaev², Gaoya Xu³, Yubo Zhou³, Jia Li⁴, Haji Akber Aisa⁵

Affiliations

¹ The State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi, 830011, China.
² S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Prosp. M. Ulugbeka, 83, Tashkent, Uzbekistan.
³ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
⁴ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao, 266237, China.
⁵ The State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi, 830011, China. Electronic address: aisa@ms.xjb.ac.cn.

PMID: 33957541
DOI: 10.1016/j.phytochem.2021.112705

Abstract

Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A-I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell with IC₅₀ values of 3.94 ± 0.06 μM and 3.87 ± 0.10 μM, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC₅₀ values of 1.48 ± 0.06 μM and 7.88 ± 0.60 μM, respectively.

Keywords: Apiaceae; Cytotoxity; Ferula samarkandica Korovin; MV-4-11 cell; Mino cell; Samarcandicins A−I; Sesquiterpene coumarin.

MeSH terms

Coumarins / pharmacology
Ferula*
Molecular Structure
Plant Roots
Sesquiterpenes* / pharmacology

Substances

Coumarins
Sesquiterpenes