Antibacterial and modulatory activities of β-cyclodextrin complexed with (+)-β-citronellol against multidrug-resistant strains

Raimundo Luiz Silva Pereira; Fábia Ferreira Campina; Maria do Socorro Costa; Rafael Pereira da Cruz; Thiago Sampaio de Freitas; Antonia Thassya Lucas Dos Santos; Beatriz Gonçalves Cruz; Diniz Maciel de Sena Júnior; Igor Kleber Campos Lima; Maria Regivânia Xavier; Alexandre Magno Rodrigues Teixeira; Irwin Rose Alencar de Menezes; Lucindo José Quintans-Júnior; Adriano A de S Araújo; Henrique Douglas Melo Coutinho

doi:10.1016/j.micpath.2021.104928

Antibacterial and modulatory activities of β-cyclodextrin complexed with (+)-β-citronellol against multidrug-resistant strains

Microb Pathog. 2021 Jul:156:104928. doi: 10.1016/j.micpath.2021.104928. Epub 2021 May 3.

Authors

Raimundo Luiz Silva Pereira¹, Fábia Ferreira Campina¹, Maria do Socorro Costa¹, Rafael Pereira da Cruz¹, Thiago Sampaio de Freitas¹, Antonia Thassya Lucas Dos Santos¹, Beatriz Gonçalves Cruz¹, Diniz Maciel de Sena Júnior¹, Igor Kleber Campos Lima¹, Maria Regivânia Xavier¹, Alexandre Magno Rodrigues Teixeira², Irwin Rose Alencar de Menezes³, Lucindo José Quintans-Júnior⁴, Adriano A de S Araújo⁵, Henrique Douglas Melo Coutinho⁶

Affiliations

¹ Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
² Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil; Department of Physics, Regional University of Cariri, Juazeiro do Norte, CE, Brazil.
³ Department of Physics, Regional University of Cariri, Juazeiro do Norte, CE, Brazil.
⁴ Department of Physiology, Federal University of Sergipe, Aracaju-SE, Brazil.
⁵ Department of Pharmacy, Federal University of Sergipe, Aracaju-SE, Brazil.
⁶ Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil. Electronic address: hdmcoutinho@gmail.com.

PMID: 33957243
DOI: 10.1016/j.micpath.2021.104928

Abstract

The present study aimed to investigate the antibacterial and modulatory activities of (+)-β-citronellol (βCT), β-cyclodextrin (β-CD), and their complex βCT/β-CD and characterize them using infrared spectroscopy. Infrared spectra were recorded in the 750-4000 cm^-1 region. The antibacterial effects of these compounds and their modulatory-antibiotic activities were determined using the minimum inhibitory concentration (MIC) test. Signatures of these pure compounds were detected in the infrared spectrum of the βCT/β-CD complex. The MIC of the βCT/β-CD complex against the tested strains was found to be 1024 μg/mL. The antagonistic and synergistic effects of these compounds were also observed using the modulation tests. βCT or β-CD alone did not exhibit any direct antibacterial activity. However, the βCT/β-CD complex in combination with gentamicin showed a synergistic effect against E. coli.

Keywords: Antibacterial activity; Infrared spectroscopy; Modulatory-antibiotic activity; β-Citronellol; β-Citronellol/β-Cyclodextrin complex; β-Cyclodextrin.

MeSH terms

Acyclic Monoterpenes
Anti-Bacterial Agents / pharmacology
Escherichia coli*
Microbial Sensitivity Tests
Staphylococcus aureus
beta-Cyclodextrins* / pharmacology

Substances

Acyclic Monoterpenes
Anti-Bacterial Agents
beta-Cyclodextrins
citronellol