The astrocyte LAMP lights a T cell TRAIL of death

Lisa Johann; Ari Waisman

doi:10.1016/j.neuron.2021.04.009

The astrocyte LAMP lights a T cell TRAIL of death

Neuron. 2021 May 5;109(9):1423-1425. doi: 10.1016/j.neuron.2021.04.009.

Authors

Lisa Johann¹, Ari Waisman²

Affiliations

¹ Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany; International PhD Program (IPP) of the Institute for Molecular Medicine (IMB) Mainz, Mainz, Germany.
² Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany; Focus Program Translational Neuroscience (FTN) Mainz, Mainz, Germany; Research Center for Immunotherapy (FZI) Mainz, Mainz, Germany. Electronic address: waisman@uni-mainz.de.

PMID: 33957071
DOI: 10.1016/j.neuron.2021.04.009

Abstract

In a recent issue of Nature, Sanmarco et al. reveal a novel mechanism by which astrocytes maintain an anti-inflammatory state in the central nervous system (CNS). IFNγ released by gut-licensed meningeal NK cells was found to induce TRAIL expression on astrocytes, causing effector T cell apoptosis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Anti-Inflammatory Agents
Astrocytes*
Central Nervous System
Killer Cells, Natural*
T-Lymphocytes

Substances

Anti-Inflammatory Agents