Abstract
Antimicrobial resistance is a growing threat to public health and an increasingly common problem for acute care physicians to confront. Several novel antibiotics have been approved in the past decade to combat these infections; however, physicians may be unfamiliar with how to appropriately utilize them. The purpose of this review is to evaluate novel antibiotics active against resistant gram-negative bacteria and highlight clinical information regarding their use in the acute care setting. This review focuses on novel antibiotics useful in the treatment of infections caused by resistant gram-negative organisms that may be seen in the acute care setting. These novel antibiotics include ceftolozane/tazobactam, ceftazidime/avibactam, meropenem/vaborbactam, imipenem/cilistatin/relebactam, cefiderocol, plazomicin, eravacycline, and omadacycline. Acute care physicians should be familiar with these novel antibiotics so they can utilize them appropriately.
Keywords:
Antibiotics; Multidrug-resistant; Novel; Resistance.
© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
MeSH terms
-
Anti-Bacterial Agents*
-
Azabicyclo Compounds / administration & dosage
-
Azabicyclo Compounds / pharmacology
-
Boronic Acids / administration & dosage
-
Boronic Acids / pharmacology
-
Cefiderocol
-
Ceftazidime / administration & dosage
-
Ceftazidime / pharmacology
-
Cephalosporins / administration & dosage
-
Cephalosporins / pharmacology
-
Cilastatin, Imipenem Drug Combination / administration & dosage
-
Cilastatin, Imipenem Drug Combination / pharmacology
-
Drug Combinations
-
Drug Design*
-
Drug Resistance, Multiple / drug effects*
-
Gram-Negative Bacteria / drug effects
-
Gram-Negative Bacterial Infections / drug therapy*
-
Heterocyclic Compounds, 1-Ring / administration & dosage
-
Heterocyclic Compounds, 1-Ring / pharmacology
-
Humans
-
Meropenem / administration & dosage
-
Meropenem / pharmacology
-
Sisomicin / administration & dosage
-
Sisomicin / analogs & derivatives
-
Sisomicin / pharmacology
-
Tazobactam / administration & dosage
-
Tazobactam / pharmacology
-
Tetracyclines / administration & dosage
-
Tetracyclines / pharmacology
Substances
-
Anti-Bacterial Agents
-
Azabicyclo Compounds
-
Boronic Acids
-
Cephalosporins
-
Drug Combinations
-
Heterocyclic Compounds, 1-Ring
-
Tetracyclines
-
avibactam, ceftazidime drug combination
-
ceftolozane, tazobactam drug combination
-
meropenem and vaborbactam
-
eravacycline
-
omadacycline
-
Cilastatin, Imipenem Drug Combination
-
Ceftazidime
-
Meropenem
-
plazomicin
-
Tazobactam
-
Sisomicin
-
relebactam