COVID-19 and HIV infection co-pandemics and their impact: a review of the literature

AIDS Res Ther. 2021 May 5;18(1):28. doi: 10.1186/s12981-021-00335-1.

Abstract

Coronavirus disease 2019 (COVID-19) was first detected in December 2019. In March 2020, the World Health Organization declared COVID-19 a pandemic. People with underlying medical conditions may be at greater risk of infection and experience complications from COVID-19. COVID-19 has the potential to affect People living with HIV (PLWH) in various ways, including be increased risk of COVID-19 acquisition and interruptions of HIV treatment and care. The purpose of this review article is to evaluate the impact of COVID-19 among PLWH. The contents focus on 4 topics: (1) the pathophysiology and host immune response of people infected with both SARS-CoV-2 and HIV, (2) present the clinical manifestations and treatment outcomes of persons with co-infection, (3) assess the impact of antiretroviral HIV drugs among PLWH infected with COVID-19 and (4) evaluate the impact of the COVID-19 pandemic on HIV services.

Keywords: COVID-19; Clinical; Co-infection; HIV; Outcome; Pathophysiology.

Publication types

  • Review

MeSH terms

  • Adult
  • Anti-Retroviral Agents / therapeutic use*
  • COVID-19 / complications
  • COVID-19 / immunology
  • COVID-19 / pathology*
  • COVID-19 Drug Treatment
  • Coinfection / immunology
  • Coinfection / pathology*
  • Cytokines / blood
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • HIV Infections / immunology
  • HIV Infections / pathology*
  • HIV-1 / immunology
  • Humans
  • Immunocompromised Host / immunology
  • Immunocompromised Host / physiology
  • Lymphopenia / pathology
  • Middle Aged
  • SARS-CoV-2 / drug effects*
  • SARS-CoV-2 / immunology*
  • Treatment Outcome

Substances

  • Anti-Retroviral Agents
  • Cytokines