He Jiankui´s gene-editing experiment and the non-identity problem

Bioethics. 2021 Jul;35(6):563-573. doi: 10.1111/bioe.12878. Epub 2021 May 5.

Abstract

Genetic engineering has been a topic of discussion for over 50 years, but it is only recently that gene editing has become a reality. CRISPR biotechnologies have made gene editing much safer, precise and feasible. We have witnessed the first cases of human germline genetic modification resulting in live births, conducted by He Jiankui. In this paper, we will analyse He Jiankui's case in relation to one of the most difficult problems in procreative ethics (or the ethics of future generations): the non-identity problem. We believe that this analysis will help us to understand the ethics involved in gene editing and hopefully allow for a better, more philosophically grounded legislation on CRISPR and other gene-editing technologies.

Keywords: CRISPR; He Jiankui; future people ethics; gene editing; non-identity; procreative ethics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clustered Regularly Interspaced Short Palindromic Repeats*
  • Gene Editing*
  • Genetic Engineering
  • Germ Cells
  • Humans