Enhanced mechanical and biological performances of CaO-MgO-SiO2 glass-ceramics via the modulation of glass and ceramic phases

Kuei-Chih Feng; Yu-Jie Wu; Chi-Yun Wang; Chi-Shun Tu; Yu-Ling Lin; Cheng-Sao Chen; Po-Liang Lai; Yu-Tzu Huang; Pin-Yi Chen

doi:10.1016/j.msec.2021.112060

Enhanced mechanical and biological performances of CaO-MgO-SiO₂ glass-ceramics via the modulation of glass and ceramic phases

Mater Sci Eng C Mater Biol Appl. 2021 May:124:112060. doi: 10.1016/j.msec.2021.112060. Epub 2021 Mar 26.

Authors

Kuei-Chih Feng¹, Yu-Jie Wu², Chi-Yun Wang³, Chi-Shun Tu⁴, Yu-Ling Lin⁵, Cheng-Sao Chen⁶, Po-Liang Lai⁷, Yu-Tzu Huang⁸, Pin-Yi Chen⁹

Affiliations

¹ Research Center for Intelligent Medical Devices, Ming Chi University of Technology, New Taipei City 24301, Taiwan; Department of Mechanical Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan.
² International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City 24301, Taiwan.
³ International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City 24301, Taiwan; Bone and Joint Research Center, Chang Gung Memorial Hospital, Taoyuan City 33305, Taiwan.
⁴ Research Center for Intelligent Medical Devices, Ming Chi University of Technology, New Taipei City 24301, Taiwan; International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City 24301, Taiwan; Department of Physics, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
⁵ School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
⁶ Department of Mechanical Engineering, Hwa Hsia University of Technology, New Taipei City 23567, Taiwan.
⁷ Bone and Joint Research Center, Chang Gung Memorial Hospital, Taoyuan City 33305, Taiwan.
⁸ School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan. Electronic address: 061337@mail.fju.edu.tw.
⁹ Research Center for Intelligent Medical Devices, Ming Chi University of Technology, New Taipei City 24301, Taiwan; International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City 24301, Taiwan; Department of Mechanical Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan. Electronic address: pinyi@mail.mcut.edu.tw.

PMID: 33947554
DOI: 10.1016/j.msec.2021.112060

Abstract

This work reports a new CaO-MgO-SiO₂ (CMS) bioactive glass-ceramic, using ZrO₂ as a nucleus to modulate the ratios of glass and ceramic phases as a function of sintering temperature. Mg-rich bioactive CMS glass-ceramics exhibit advantages regarding mechanical strength (flexural strength ~190 MPa and compressive strength ~555 MPa), in-vitro and in-vivo biocompatibilities, and bone ingrowth. The high mechanical strengths could be attributed to the CaMgSi₂O₆ glass-ceramic and lower porosity. X-ray absorption spectra indicate an increased SiO covalent bond via the development of CaMgSi₂O₆ glass-ceramics. From the in-vitro cytotoxicity and BMSC differentiation assays, the CMS samples sintered above 800 °C exhibited better cell attachment and differentiation, possibly due to structural stability, appropriate pore, and ion release to boost osteogenesis. Compared to hydroxyapatite (HA) ceramics, the CMS glass-ceramics display higher mechanical strengths, biocompatibility, and osteoconductivity. An in-vivo experiment demonstrated a fine bone-ingrowth profile around the CMS implant. This study may further the application of CMS glass-ceramics in bone implants.

Keywords: Biocompatibility; CaO-MgO-SiO(2) glass-ceramics; Mechanical strength.

MeSH terms

Ceramics
Durapatite
Glass
Magnesium Oxide*
Silicon Dioxide*

Substances

Magnesium Oxide
Silicon Dioxide
Durapatite