Recent advances in bioprinting technologies for engineering cardiac tissue

Tarun Agarwal; Gabriele Maria Fortunato; Sung Yun Hann; Bugra Ayan; Kiran Yellappa Vajanthri; Dario Presutti; Haitao Cui; Alex H P Chan; Marco Costantini; Valentina Onesto; Concetta Di Natale; Ngan F Huang; Pooyan Makvandi; Majid Shabani; Tapas Kumar Maiti; Lijie Grace Zhang; Carmelo De Maria

doi:10.1016/j.msec.2021.112057

Recent advances in bioprinting technologies for engineering cardiac tissue

Mater Sci Eng C Mater Biol Appl. 2021 May:124:112057. doi: 10.1016/j.msec.2021.112057. Epub 2021 Mar 25.

Authors

Tarun Agarwal¹, Gabriele Maria Fortunato², Sung Yun Hann³, Bugra Ayan⁴, Kiran Yellappa Vajanthri⁵, Dario Presutti⁶, Haitao Cui³, Alex H P Chan⁴, Marco Costantini⁶, Valentina Onesto⁷, Concetta Di Natale⁸, Ngan F Huang⁹, Pooyan Makvandi¹⁰, Majid Shabani¹⁰, Tapas Kumar Maiti¹¹, Lijie Grace Zhang¹², Carmelo De Maria¹³

Affiliations

¹ Department of Biotechnology, Indian Institute of Technology Kharagpur, West Bengal 721302, India.
² Research Center "E. Piaggio" and Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy.
³ Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
⁴ Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
⁵ School of Biomedical Engineering, Indian Institute of Technology Banaras Hindu University Varanasi, Uttar Pradesh 221005, India.
⁶ Institute of Physical Chemistry - Polish Academy of Sciences, Warsaw, Poland.
⁷ Institute of Nanotechnology, National Research Council (CNR-NANOTEC), Campus Ecotekne, via Monteroni, Lecce 73100, Italy.
⁸ Center for Advanced Biomaterial for Health Care (CABHC), Istituto Italiano di Tecnologia, Naples, Italy; Interdisciplinary Research Centre on Biomaterials (CRIB), University of Naples Federico II, P.leTecchio 80, Naples 80125, Italy.
⁹ Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
¹⁰ Center for Materials Interface, Istituto Italiano di Tecnologia, Pontedera 56025, Pisa, Italy.
¹¹ Department of Biotechnology, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address: tkmaiti@hijli.iitkgp.ernet.in.
¹² Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA; Department of Electrical and Computer Engineering, The George Washington University, Washington, DC 20052, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA; Department of Medicine, The George Washington University, Washington, DC 20052, USA. Electronic address: lgzhang@email.gwu.edu.
¹³ Research Center "E. Piaggio" and Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy. Electronic address: carmelo.demaria@unipi.it.

Abstract

Annually increasing incidence of cardiac-related disorders and cardiac tissue's minimal regenerative capacity have motivated the researchers to explore effective therapeutic strategies. In the recent years, bioprinting technologies have witnessed a great wave of enthusiasm and have undergone steady advancements over a short period, opening the possibilities for recreating engineered functional cardiac tissue models for regenerative and diagnostic applications. With this perspective, the current review delineates recent developments in the sphere of engineered cardiac tissue fabrication, using traditional and advanced bioprinting strategies. The review also highlights different printing ink formulations, available cellular opportunities, and aspects of personalized medicines in the context of cardiac tissue engineering and bioprinting. On a concluding note, current challenges and prospects for further advancements are also discussed.

Keywords: Bioprinting; Cardiac tissue engineering; Cardio-inductive microenvironment; Stem cells.

Publication types

Review

MeSH terms

Bioprinting*
Heart
Ink
Printing, Three-Dimensional
Tissue Engineering

Abstract

Publication types

MeSH terms

Grants and funding