The Molecular Bases Study of the Inherited Diseases for the Health Maintenance of the Beef Cattle

Genes (Basel). 2021 Apr 30;12(5):678. doi: 10.3390/genes12050678.

Abstract

The article highlighted the problem of meat cattle genetic defects. The aim was the development of DNA tests for some genetic defects diagnostics, the determination of the animal carriers and their frequencies tracking in time. The 1490 DNA samples from the Aberdeen Angus (n = 701), Hereford (n = 385), Simmental (n = 286) and Belgian Blue (n = 118) cattle have been genotyped on the genetic defects by newly created and earlier developed DNA tests based on AS-PCR and PCR-RFLP methods. The Aberdeen Angus cattle genotyping has revealed 2.38 ± 0.31% AMC-cows and 1.67 ± 0.19 % AMC-bulls, 0.65 ± 0.07% DDC-cows and 0.90 ± 0.10% DDC-bulls. The single animals among the Hereford cattle were carriers of MSUD and CWH (on 0.27 ± 0.05%), ICM and HY (on 0.16 ± 0.03%). The Simmental cattle were free from OS. All Belgian Blue livestock were M1- and 0.84%-CMD1-carriers. The different ages Aberdeen Angus cattle genotyping has shown the tendency of the AMC- and DDC frequencies to increase in the later generations. The statistically significant increase of DDC of 1.17% in the cows' population born in 2019 compared to those born in 2015 allows concluding the further development of the DNA analysis-based measures preventing the manifestation of the genetic anomalies in meat cattle herds is necessary.

Keywords: Aberdeen Angus; Belgian Blue; Hereford; Simmental; congenital diseases; gene mutations; genetic defects; meat cattle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle / genetics*
  • Cattle Diseases / diagnosis
  • Cattle Diseases / genetics*
  • Genetic Carrier Screening / methods
  • Genetic Carrier Screening / standards
  • Genetic Carrier Screening / veterinary*
  • Genotyping Techniques / methods
  • Genotyping Techniques / standards
  • Genotyping Techniques / veterinary
  • Polymerase Chain Reaction / methods
  • Polymerase Chain Reaction / standards
  • Sensitivity and Specificity