Plasma Rich in Growth Factors (PRGF) in Transepithelial Photorefractive Keratectomy (TPRK)

José-María Sánchez-González; Federico Alonso-Aliste; Davide Borroni; Jonatan Amián-Cordero; Concepción De-Hita-Cantalejo; Raúl Capote-Puente; María-José Bautista-Llamas; María Carmen Sánchez-González; Marina Rodríguez-Calvo-de-Mora; Carlos Rocha-de-Lossada

doi:10.3390/jcm10091939

Plasma Rich in Growth Factors (PRGF) in Transepithelial Photorefractive Keratectomy (TPRK)

J Clin Med. 2021 Apr 30;10(9):1939. doi: 10.3390/jcm10091939.

Authors

Affiliations

¹ Department of Physics of Condensed Matter, Optics Area, University of Seville, 41012 Seville, Spain.
² Department of Ophthalmology, Tecnolaser Clinic Vision, 41018 Seville, Spain.
³ The Veneto Eye Bank Foundation, 30174 Venice, Italy.
⁴ Department of Doctoral Studies, Riga Stradins University, LV-1007 Riga, Latvia.
⁵ Department of Ophthalmology, Regional University Hospital of Malaga, 29010 Malaga, Spain.
⁶ Department of Ophthalmology (Qvision), Vithas Virgen del Mar Hospital, 04120 Almería, Spain.
⁷ Department of Ophthalmology, University Hospital Virgen de las Nieves, 18014 Granada, Spain.
⁸ Department of Ophthalmology, Ceuta Medical Center, 51001 Ceuta, Spain.

Abstract

To evaluate the usage of plasma rich in growth factor (PRGF) in transepithelial photorefractive keratectomy (TPRK) in low and moderate myopia, patients who underwent myopic and astigmatism TPRK with PRGF were involved in this retrospective, observational study. Subjects underwent a surgical procedure between February 2019 and June 2019. A three-month follow-up was recorded. Pain score was assessed with a visual analogue scale (0-10) and re-epithelialization time recorded. A total of 48 eyes from 24 patients were recruited. Mean uncorrected distance visual acuity (UDVA) was 20/20.31 (0.00 ± 0.02 LogMAR). A total of 98% of eyes did not change corrected distance visual acuity (CDVA) lines. Two percent of eyes lost one line of CDVA. Preoperative spherical equivalent was -2.67 ± 1.37 D and after three months changed to -0.21 ± 0.34 D, and 2% of eyes changed 0.50 D or more between one and three months. Pain score was 3.29 ± 0.61 (3 to 6) score points at day one and 0.08 ± 0.27 score points at day seven. Finally, re-epithelialization time was 2.50 ± 1.20 days. PRGF addition to conventional refractive treatment such as TPRK seems to alleviate immediate postoperative pain and positively contribute to corneal re-epithelization time.

Keywords: photorefractive keratectomy; plasma rich in growth factor; refractive outcomes; transepithelial photorefractive keratectomy; visual outcomes.