Unraveling the role of oxidative stress and lipid status parameters in the onset of preeclampsia

Hypertens Pregnancy. 2021 May;40(2):162-170. doi: 10.1080/10641955.2021.1921790. Epub 2021 May 3.

Abstract

OBJECTIVE: The aim of the study was to assess the potential role of oxidative stress and lipid status in the onset of preeclampsia.METHODS: 138 high-risk pregnant women were prospectively followed. Assessment of oxidative stress (TAS, TOS, AOPP and SH groups) and lipid status (t-C, LDL-C, HDL-C, TGC, APO-A1, APO-B) was carried out during the pregnancy.RESULTS: 30 women developed preeclampsia. TGC, atherogenic index of plasma, TAS and SH levels were higher in women who subsequently developed preeclampsia (p<0.05).CONCLUSION: Oxidative stress and lipid status disturbance have a potential role in the onset of preeclampsia in high risk pregnancies.

Keywords: lipid status; oxidative stress; preeclampsia.

MeSH terms

  • Adult
  • Antioxidants / metabolism*
  • Apolipoprotein A-I / blood
  • Apolipoproteins B / blood
  • Biomarkers / blood
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Female
  • Humans
  • Lipids / blood*
  • Oxidative Stress / physiology*
  • Pre-Eclampsia / blood
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / metabolism
  • Pregnancy
  • Pregnancy, High-Risk
  • Prospective Studies
  • Triglycerides / blood

Substances

  • Antioxidants
  • Apolipoprotein A-I
  • Apolipoproteins B
  • Biomarkers
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Lipids
  • Triglycerides
  • Cholesterol