An automated radiosynthesis of (S)-[18F]28 for PET imaging of Alzheimer's disease

Ji-Kui Xie; Xing-Xing Zhu; Kai-Xuan Wang; Shi-Cun Wang; Qiang Xie

doi:10.1016/j.apradiso.2021.109740

An automated radiosynthesis of (S)-[¹⁸F]28 for PET imaging of Alzheimer's disease

Appl Radiat Isot. 2021 Aug:174:109740. doi: 10.1016/j.apradiso.2021.109740. Epub 2021 Apr 27.

Authors

Ji-Kui Xie¹, Xing-Xing Zhu¹, Kai-Xuan Wang¹, Shi-Cun Wang¹, Qiang Xie²

Affiliations

¹ Department of Nuclear Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
² Department of Nuclear Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China. Electronic address: xieqiang1980@ustc.edu.cn.

PMID: 33940354
DOI: 10.1016/j.apradiso.2021.109740

Abstract

¹⁸F-labeled 2-arylbenzoxazole derivative (S)-[¹⁸F]28 is potent and selective radiopharmaceutical Aβ tracers for Alzheimer's disease positron-emission tomography (PET). Our study aimed to enable facile preparation of (S)-[¹⁸F]28 in commercially available PET tracer production facilities to promote the widespread application and clinical translation. Here, we successfully demonstrated an automated radiosynthesis of (S)-[¹⁸F]28 with high radiochemical yield and radiochemical purity by the AllinOne radiosynthesis module. The method developed here can facilitate extensive use of (S)-[¹⁸F]28 in large-scale clinical trials.

Keywords: (S)-[(18)F]28; Alzheimer's disease; Automated radiosynthesis; Aβ tracers; PET-CT.

MeSH terms

Alzheimer Disease / diagnostic imaging*
Automation
Fluorine Radioisotopes / chemistry*
Humans
Positron-Emission Tomography / methods*
Radiochemistry / methods*
Radiopharmaceuticals / chemical synthesis*

Substances

Fluorine Radioisotopes
Radiopharmaceuticals
Fluorine-18