1 Champalimaud Foundation, Lisbon, Portugal Angelita & Joaquim Gama Institute, University of São Paulo School of Medicine, Colorectal Surgery Division, Sao Paulo, Brazil Angelita & Joaquim Gama Institute, Sao Paulo, Brazil Champalimaud Foundation, Lisbon, Portugal Angelita & Joaquim Gama Institute, Sao Paulo, Brazil Champalimaud Foundation, Lisbon, Portugal Angelita & Joaquim Gama Institute, University of São Paulo School of Medicine, Colorectal Surgery Division, Ludwig Institute for Cancer Research São Paulo Branch, Sao Paulo, Brazil.