Cardiovascular Issues in Hematopoietic Stem Cell Transplantation (HSCT)

Curr Treat Options Oncol. 2021 Apr 30;22(6):51. doi: 10.1007/s11864-021-00850-3.

Abstract

Hematopoietic stem cell transplantation (HSCT) is considered, since 1957, a potentially curative therapeutic option for many hemopathies. Although it is an aggressive procedure, improvements in transplantation techniques and supportive strategies have markedly decreased treatment-related mortality, and the prevalence of HSCT survivors is expected to exceed half a million by 2030. At the same time, there is a growing awareness of the potentially negative effects of HSCT-related therapies on the cardiovascular (CV) system, and HSCT survivors constitute a population at high cardiovascular (CV) risk. Cardio-oncology has been proposed as a new approach to prevent cardiovascular toxicity during and after HSCT. The present article attempts to provide a multidisciplinary and practical approach to the prevention, monitoring, and management of the most common cardiovascular complications in patients undergoing hematopoietic stem cell transplantation.

Keywords: Cardio-oncology; Cardiotoxicity; Echocardiography; Heart failure; Hematopoietic stem cell transplantation; Hypertension.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology*
  • Cardiovascular Diseases / prevention & control
  • Cardiovascular Diseases / therapy
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Risk Factors