The interplay between Helicobacter pylori and gastrointestinal microbiota

Gut Microbes. 2021 Jan-Dec;13(1):1-22. doi: 10.1080/19490976.2021.1909459.

Abstract

The complex population of microbes in the human gastrointestinal (GI) tract interacts with itself and with the host, exerting a deep influence on health and disease development. The development of modern sequencing technology has enabled us to gain insight into GI microbes. Helicobacter pylori colonization significantly affects the gastric microenvironment, which in turn affects gastric microbiota and may be correlated with colonic microbiota changes. Crosstalk between H. pylori and GI commensal flora may play a role in H. pylori-related carcinogenicity and extragastric manifestations. We review current knowledge on how H. pylori shapes GI microbiota with a specific focus on its impact on the stomach and colon. We also review current evidence on colonic microbiota changes attributed to eradication therapy based on the clinical studies performed to date.

Keywords: Helicobacter pylori; colonic microbiota; eradication therapy; esophageal microbiota; gastric cancer; gastric microbiota.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinogenesis*
  • Colon / microbiology
  • Disease Eradication / methods
  • Gastrointestinal Microbiome*
  • Helicobacter Infections / immunology*
  • Helicobacter Infections / microbiology*
  • Helicobacter Infections / therapy
  • Helicobacter pylori*
  • Humans
  • Microbial Viability*
  • Stomach / microbiology
  • Stomach Neoplasms / microbiology*
  • Stomach Neoplasms / therapy

Grants and funding

This work was supported by the Ministry of Education [NTU-107L9014-1]; Ministry of Health and Welfare [MOHW107-TDU-B-211-123002, MOHW108-CDC-C-114-112102]; Ministry of Science and Technology, Taiwan [MOST 108-2314-B-002-187, 108-2314-B-002-209-]; Ministry of Science and Technology, Taiwan [TCTC 108-2321-B-002-040-]; National Taiwan University Hospital [NTUH 107-P05; 107-T11; 109-P03]; ; St George and Sutherland Medical Research Foundation [N/A]; Liver Disease Prevention & Treatment Research Foundation, Taiwan.