Quantitative assessment of structural and functional changes in temporal lobe epilepsy with hippocampal sclerosis

Jiajie Mo; Baotian Zhao; Sophie Adler; Jianguo Zhang; Xiaoqiu Shao; Yanshan Ma; Lin Sang; Wenhan Hu; Chao Zhang; Yao Wang; Xiu Wang; Chang Liu; Kai Zhang

doi:10.21037/qims-20-624

Quantitative assessment of structural and functional changes in temporal lobe epilepsy with hippocampal sclerosis

Quant Imaging Med Surg. 2021 May;11(5):1782-1795. doi: 10.21037/qims-20-624.

Authors

Jiajie Mo^{1

2

3}, Baotian Zhao^{1

2

3}, Sophie Adler⁴, Jianguo Zhang^{1

2

3}, Xiaoqiu Shao^{3

5}, Yanshan Ma⁶, Lin Sang⁶, Wenhan Hu^{1

2

3}, Chao Zhang^{1

2

3}, Yao Wang^{1

2

3}, Xiu Wang^{1

2

3}, Chang Liu^{1

2

3}, Kai Zhang^{1

2

3}

Affiliations

¹ Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
² Department of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
³ China National Clinical Research Center for Neurological Diseases, Beijing, China.
⁴ Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
⁵ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
⁶ Department of Neurosurgery, Beijing Fengtai Hospital, Beijing, China.

Abstract

Background: Magnetic resonance imaging (MRI) changes in hippocampal sclerosis (HS) could be subtle in a significant proportion of mesial temporal lobe epilepsy (mTLE) patients. In this study, we aimed to document the structural and functional changes in the hippocampus and amygdala seen in HS patients.

Methods: Quantitative features of the hippocampus and amygdala were extracted from structural MRI data in 66 mTLE patients and 28 controls. Structural covariance analysis was undertaken using volumetric data from the amygdala and hippocampus. Functional connectivity (FC) measured using resting intracranial electroencephalography (EEG) was analyzed in 22 HS patients and 16 non-HS disease controls.

Results: Hippocampal atrophy was present in both MRI-positive and MRI-negative HS groups (Mann-Whitney U: 7.61, P<0.01; Mann-Whitney U: 6.51, P<0.01). Amygdala volumes were decreased in the patient group (Mann-Whitney U: 2.92, P<0.05), especially in MRI-negative HS patients (Mann-Whitney U: 2.75, P<0.05). The structural covariance analysis showed the normalized volumes of the amygdala and hippocampus were tightly coupled in both controls and HS patients (ρ_Spearman =0.72, P<0.01). FC analysis indicated that HS patients had significantly increased connectivity (Student's t: 2.58, P=0.03) within the hippocampus but decreased connectivity between the hippocampus and amygdala (Student's t: 3.33, P=0.01), particularly for MRI-negative HS patients.

Conclusions: Quantitative structural changes, including hippocampal atrophy and temporal pole blurring, are present in both MRI-positive and MRI-negative HS patients, suggesting the potential usefulness of incorporating quantitative analyses into clinical practice. HS is characterized by increased intra-hippocampal EEG synchronization and decreased coupling between the hippocampus and amygdala.

Keywords: Hippocampal sclerosis (HS); functional connectivity (FC); mesial temporal lobe epilepsy (mTLE); quantitative structural analysis.