Plasma free metanephrine and normethanephrine levels correlated to plasma catecholamine after acute running in amateur runner

Katsuyuki Tokinoya; Yasuhiro Shishikura; Nanami Sekine; Atsushi Aoyagi; Yasuko Yoshida; Yuichi Aita; Takehito Sugasawa; Yoshiharu Nabekura; Kazuhiro Takekoshi

doi:10.1016/j.jesf.2021.03.002

Plasma free metanephrine and normethanephrine levels correlated to plasma catecholamine after acute running in amateur runner

J Exerc Sci Fit. 2021 Jul;19(3):178-181. doi: 10.1016/j.jesf.2021.03.002. Epub 2021 Mar 19.

Authors

Katsuyuki Tokinoya¹, Yasuhiro Shishikura², Nanami Sekine², Atsushi Aoyagi², Yasuko Yoshida^{1

3}, Yuichi Aita¹, Takehito Sugasawa¹, Yoshiharu Nabekura⁴, Kazuhiro Takekoshi¹

Affiliations

¹ Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
² Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
³ Department of Clinical Laboratory Science, Faculty of Health Sciences, Tsukuba International University, Japan.
⁴ Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.

Abstract

Background: Catecholamine is a typical index of exercise intensity, but it is difficult to detect. Plasma metanephrine (MN) and normethanephrine (NMN) levels are more stable than those of catecholamines. This study aimed to investigate plasma MN and NMN levels during acute exercise running in amateur runners.

Methods: Samples were collected from eight healthy male participants. They were either sedentary or running at low or high intensity for 30 min. Blood samples were collected under these conditions. Measurements taken included plasma adrenaline, noradrenaline, MN, and NMN.

Results: Plasma adrenaline levels increased after high-intensity exercise compared with sedentary subjects. Plasma noradrenaline, MN, and NMN levels increased after both low- and high-intensity exercise compared with sedentary subjects. In addition, these levels were also significantly higher at high intensity than at low intensity. Plasma adrenaline and noradrenaline levels were positively correlated with plasma free MN and NMN levels after acute running, respectively.

Conclusion: This study revealed that plasma MN and NMN levels transiently increased depending on exercise intensity in amateur runners. In addition, plasma NMN levels are better markers than plasma MN levels because of their stronger correlation with plasma catecholamine levels.

Keywords: Exercise; Intensity; Running; Ventilatory threshold.

Publication types

Case Reports