Aflatoxicosis in Pekin duckling and the effects of treatments with lycopene and silymarin

Sahar M El-Sheshtawy; Amal F El-Zoghby; Nesreen A Shawky; Dalia H Samak

doi:10.14202/vetworld.2021.788-793

Aflatoxicosis in Pekin duckling and the effects of treatments with lycopene and silymarin

Vet World. 2021 Mar;14(3):788-793. doi: 10.14202/vetworld.2021.788-793. Epub 2021 Mar 29.

Authors

Sahar M El-Sheshtawy¹, Amal F El-Zoghby², Nesreen A Shawky², Dalia H Samak³

Affiliations

¹ Toxicology Animal Health Research Institute, Tanta Branch, Agriculture Research Centre, Giza, Egypt.
² Animal Health Research Institute, Tanta and Zagazig Branch, Agriculture Research Centre, Giza, Egypt.
³ Department of Veterinary Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Egypt.

Abstract

Background and aim: Aflatoxins (AFs) are potent toxic metabolites produced from Aspergillus species. Whose existence in poultry ration leads to drastic economic losses, notably in duck, as the most susceptible poultry species. This study aimed to determine tissue residues of AFs, alterations in selected clinical chemistry variables in serum, mainly during the exposure period, and lycopene and silymarin's possible roles as herbal treatments against aflatoxicosis in Pekin duckling.

Materials and methods: The study used one hundred and twenty one-day-old Pekin ducklings and classified them into four groups comprising 30 ducklings in each group. The control group (G1) ducklings were fed a mycotoxin-free ration, and G2 received a naturally contaminated ration with 30 ppb of AFs. G3 and G4 consumed contaminated rations with AFs with 30 ppb for 2 weeks and were treated with lycopene 100 mg/kg or silymarin 600 mg/kg/food, respectively, for 10 days. Serum activities of alanine transaminase and alkaline phosphatase (ALP), glutamyl transferase, ALP, total protein and albumin creatinine and uric acid concentrations, oxidant/antioxidant parameters (malondialdehyde [MDA], total antioxidant capacity (TAC), glutathione S-transferase (GST), and catalase [CAT]), and hepatic AFs residue were determined. Lycopene and silymarin were used for the treatment of aflatoxicosis for another 10 days.

Results: Hepatic and kidney parameters were elevated in the AFs intoxicated group and reduced in the lycopene- and silymarin-treated groups. They had elevated MDA and AFs residues with decreased antioxidant parameters (TAC, GST, and CAT) in the AFs group. At the same time, treatment with lycopene or silymarin had reversed the action of AFs on MDA, elevated the hepatic residue, and improved antioxidant activity.

Conclusion: Lycopene and silymarin, with their potent antioxidant activity, can be used to reverse the harmful effects of AFs on hepatic and kidney tissue.

Keywords: aflatoxins; aspergillus; creatinine; hepatic; kidney; lycopene; mycotoxicosis; oxidative stress; pekin duckling; residue; silymarin.