FXYD1 Is Protective Against Vascular Dysfunction

Kristen J Bubb; Owen Tang; Carmine Gentile; Seyed M Moosavi; Thomas Hansen; Chia-Chi Liu; Belinda A Di Bartolo; Gemma A Figtree

doi:10.1161/HYPERTENSIONAHA.120.16884

FXYD1 Is Protective Against Vascular Dysfunction

Hypertension. 2021 Jun;77(6):2104-2116. doi: 10.1161/HYPERTENSIONAHA.120.16884. Epub 2021 May 3.

Authors

Kristen J Bubb^#^{1

2}, Owen Tang^#^{1

3}, Carmine Gentile^{1

4}, Seyed M Moosavi^{1

4}, Thomas Hansen^{1

3}, Chia-Chi Liu^{1

3

5}, Belinda A Di Bartolo^{1

3}, Gemma A Figtree^{1

3}

Affiliations

¹ From the University of Sydney, Kolling Institute of Medical Research, Cardiothoracic and Vascular Health (K.J.B., O.T., C.G., S.M.M., T.H., C.-C.L., B.A.D.B., G.A.F.).
² Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia (K.J.B.).
³ Royal North Shore Hospital, St Leonards, NSW, Australia (O.T., T.H., C.-C.L., B.A.D.B., G.A.F.).
⁴ University of Technology Sydney, Ultimo, NSW, Australia (C.G., S.M.M.).
⁵ Heart Research Institute, Newtown, NSW, Australia (C.-C.L.).

^# Contributed equally.

PMID: 33934624
DOI: 10.1161/HYPERTENSIONAHA.120.16884

Abstract

[Figure: see text].

Keywords: blood pressure; exosomes; nitric oxide; superoxide; vasodilation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Pressure / physiology*
Coculture Techniques
Endothelium, Vascular / metabolism*
Endothelium, Vascular / physiopathology
Human Umbilical Vein Endothelial Cells / metabolism
Humans
Membrane Proteins / genetics
Membrane Proteins / metabolism*
Mice
Mice, Knockout
Nitric Oxide / metabolism
Nitric Oxide Synthase Type III / metabolism
Oxidative Stress / physiology*
Phosphoproteins / genetics
Phosphoproteins / metabolism*

Substances

Membrane Proteins
Phosphoproteins
phospholemman
Nitric Oxide
Nitric Oxide Synthase Type III