Production of 52Mn using a semi-automated module

Jennifer M Pyles; Adriana V F Massicano; Jean-Pierre Appiah; Jennifer L Bartels; Aaron Alford; Suzanne E Lapi

doi:10.1016/j.apradiso.2021.109741

Production of ⁵²Mn using a semi-automated module

Appl Radiat Isot. 2021 Aug:174:109741. doi: 10.1016/j.apradiso.2021.109741. Epub 2021 Apr 23.

Authors

Jennifer M Pyles¹, Adriana V F Massicano², Jean-Pierre Appiah², Jennifer L Bartels², Aaron Alford¹, Suzanne E Lapi³

Affiliations

¹ Department of Radiology, The University of Alabama at Birmingham, Birmingham, AL, USA; Department of Chemistry, The University of Alabama at Birmingham, Birmingham, AL, USA.
² Department of Radiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
³ Department of Radiology, The University of Alabama at Birmingham, Birmingham, AL, USA; Department of Chemistry, The University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: lapi@uab.edu.

PMID: 33933840
DOI: 10.1016/j.apradiso.2021.109741

Abstract

This work focused on the production and purification of the positron emitter ⁵²Mn (t_1/2 = 5.6 d) via the ^natCr(p,n)⁵²Mn reaction, using a TR24 cyclotron and a semi-automated system for the purification of ⁵²Mn. Based on two-column and three-column systems, the recovery of ⁵²Mn was 79.7 ± 6.2% (n = 3) and 70.8 ± 3.3% (n = 3), with processing times of 6.9 ± 0.5 h and 8.2 ± 0.6 h, respectively.

Keywords: Chemistry; Chromium; Cr-52; Cyclotron; Cyclotron target design; DOTA; Fluidic system design; HPGe; ICP-MS; Mn; Mn-52; Positron; Production purification; Proton irradiation; Radioactivity Manganese-52; Radiochemistry; Radiology; Semi-automated system.