Mouse models for actinic keratoses

Justin Choi; Cameron E West; Youkyung S Roh; Nishadh Sutaria; Shawn G Kwatra; Madan M Kwatra

doi:10.1016/j.vascn.2021.107071

Mouse models for actinic keratoses

J Pharmacol Toxicol Methods. 2021 Jul-Aug:110:107071. doi: 10.1016/j.vascn.2021.107071. Epub 2021 Apr 30.

Authors

Justin Choi¹, Cameron E West², Youkyung S Roh¹, Nishadh Sutaria¹, Shawn G Kwatra³, Madan M Kwatra⁴

Affiliations

¹ Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
² ProPath, Dallas, TX 75247, USA.
³ Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address: skwatra1@jhmi.edu.
⁴ Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.

PMID: 33933627
DOI: 10.1016/j.vascn.2021.107071

Abstract

Actinic keratoses (AKs) represent a premalignant skin condition due to chronic sun damage that dramatically increases in prevalence in the aging population. Currently, animal models of AKs utilize photocarcinogenesis, chemical carcinogens, or targeted gene modulation, and each method possesses unique strengths and weaknesses. Models using photodamage most comprehensively describe methods for preferentially selecting AK lesions, while replicating the pathogenesis of AKs with greater fidelity than models utilizing other carcinogenic methods. The following review of current murine models of AKs will aid in the selection of mouse models appropriate for future in vivo studies to test the efficacy of novel therapeutic agents for the treatment of AKs.

Keywords: Actinic keratosis; DMBA/TPA; Mouse model; Skin cancer; Squamous cell carcinoma; UVB.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Keratosis, Actinic*
Mice