Moments in autophagy and disease: Past and present

Xin Wen; Ying Yang; Daniel J Klionsky

doi:10.1016/j.mam.2021.100966

Moments in autophagy and disease: Past and present

Mol Aspects Med. 2021 Dec:82:100966. doi: 10.1016/j.mam.2021.100966. Epub 2021 Apr 28.

Authors

Xin Wen¹, Ying Yang¹, Daniel J Klionsky²

Affiliations

¹ Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
² Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: klionsky@umich.edu.

Abstract

Over the past several decades, research on autophagy, a highly conserved lysosomal degradation pathway, has been advanced by studies in different model organisms, especially in the field of its molecular mechanism and regulation. The malfunction of autophagy is linked to various diseases, among which cancer and neurodegenerative diseases are the major focus. In this review, we cover some other important diseases, including cardiovascular diseases, infectious and inflammatory diseases, and metabolic disorders, as well as rare diseases, with a hope of providing a more complete understanding of the spectrum of autophagy's role in human health.

Keywords: Autophagy; COVID-19; Cardiovascular diseases; Metabolic disorders; Rare diseases.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Autophagy
Humans
Lysosomes
Neoplasms* / genetics
Neurodegenerative Diseases* / genetics

Grants and funding

R35 GM131919/GM/NIGMS NIH HHS/United States