The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics

Guo Zhao; Chuan Liu; Xin Wen; Gan Luan; Longxiang Xie; Xiangqian Guo

doi:10.1016/j.pharmthera.2021.107881

The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics

Pharmacol Ther. 2021 Nov:227:107881. doi: 10.1016/j.pharmthera.2021.107881. Epub 2021 Apr 28.

Authors

Guo Zhao¹, Chuan Liu¹, Xin Wen¹, Gan Luan², Longxiang Xie³, Xiangqian Guo⁴

Affiliations

¹ Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
² Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ 07102, USA.
³ Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China. Electronic address: xielongxiang123@126.com.
⁴ Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China. Electronic address: xqguo@henu.edu.cn.

PMID: 33930453
DOI: 10.1016/j.pharmthera.2021.107881

Abstract

Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM) family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved in multiple cellular processes and signaling pathways. TRIM proteins have critical effects in the regulation of biological behaviors of cancer cells. Here, we discussed the current understanding of the molecular mechanism of TRIM proteins regulation of cancer cells. We also comprehensively reviewed published studies on TRIM family members as oncogenes or tumor suppressors in the oncogenesis, development, and progression of a variety of types of human cancers. Finally, we highlighted that certain TRIM family members are potential molecular biomarkers for cancer diagnosis and prognosis, and potential therapeutic targets.

Keywords: Cancer; Diagnosis; Inhibitor; Prognosis; TRIM; Therapeutic targets.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Neoplasms* / drug therapy
Neoplasms* / genetics
Protein Domains* / drug effects
Protein Domains* / genetics
Protein Domains* / physiology