SARS-CoV-2 RNA: Exclusive friends and common foes

Emmanuelle V LeBlanc; Che C Colpitts

doi:10.1016/j.cell.2021.04.009

SARS-CoV-2 RNA: Exclusive friends and common foes

Cell. 2021 Apr 29;184(9):2276-2278. doi: 10.1016/j.cell.2021.04.009.

Authors

Emmanuelle V LeBlanc¹, Che C Colpitts²

Affiliations

¹ Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
² Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada. Electronic address: che.colpitts@queensu.ca.

Abstract

Infection with SARS-CoV-2 sets off a molecular arms race between virus replication and host cell defense. In this issue of Cell, Flynn, Belk, et al. integrate an advanced large-scale RNA-centered approach with custom CRISPR screens to functionally characterize the interactome of the SARS-CoV-2 RNA genome during infection.

Publication types

Comment

MeSH terms

COVID-19*
Friends
Host-Pathogen Interactions / genetics
Humans
RNA, Viral / genetics
SARS-CoV-2*

Substances

RNA, Viral