Radiogenomics of Gliomas

Chaitra Badve; Sangam Kanekar

doi:10.1016/j.rcl.2021.02.002

Radiogenomics of Gliomas

Radiol Clin North Am. 2021 May;59(3):441-455. doi: 10.1016/j.rcl.2021.02.002.

Authors

Chaitra Badve¹, Sangam Kanekar²

Affiliations

¹ Department of Radiology, Division of Neuroradiology, University Hospitals Cleveland Medical Center, BSH 5056, 11100 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: Chaitra.Badve@UHhospitals.org.
² Department of Radiology and Neurology, Division of Neuroradiology, Penn State College of Medicine, Penn State Milton Hershey Medical Center, Mail Code H066 500, University Drive, Hershey, PA 17033, USA.

PMID: 33926688
DOI: 10.1016/j.rcl.2021.02.002

Abstract

The 2016 World Health Organization brain tumor classification is based on genomic and molecular profile of tumor tissue. These characteristics have improved understanding of the brain tumor and played an important role in treatment planning and prognostication. There is an ongoing effort to develop noninvasive imaging techniques that provide insight into tissue characteristics at the cellular and molecular levels. This article focuses on the molecular characteristics of gliomas, transcriptomic subtypes, and radiogenomic studies using semantic and radiomic features. The limitations and future directions of radiogenomics as a standalone diagnostic tool also are discussed.

Keywords: 1p/19q codeletion; Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF); Gliomagenesis; Isocitrate dehydrogenase (IDH); Radiogenomics; Radiomics; The cancer genome atlas (TCGA); Visually accessible rembrandt imaging (VASARI) feature set.

Publication types

Review

MeSH terms

Brain / diagnostic imaging
Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / genetics*
Diagnostic Imaging / methods*
Glioma / diagnostic imaging*
Glioma / genetics*
Humans
Imaging Genomics / methods*