Self-Associating Polymers Chitosan and Hyaluronan for Constructing Composite Membranes as Skin-Wound Dressings Carrying Therapeutics

Molecules. 2021 Apr 26;26(9):2535. doi: 10.3390/molecules26092535.

Abstract

Chitosan, industrially acquired by the alkaline N-deacetylation of chitin, belongs to β-N-acetyl-glucosamine polymers. Another β-polymer is hyaluronan. Chitosan, a biodegradable, non-toxic, bacteriostatic, and fungistatic biopolymer, has numerous applications in medicine. Hyaluronan, one of the major structural components of the extracellular matrix in vertebrate tissues, is broadly exploited in medicine as well. This review summarizes that these two biopolymers have a mutual impact on skin wound healing as skin wound dressings and carriers of remedies.

Keywords: MitoQ; SkQ; antioxidants; chitin; hyaluronic acid; l-(+)-ergothioneine; resveratrol; wound healing.

Publication types

  • Review

MeSH terms

  • Bandages*
  • Biopolymers / chemistry*
  • Chitosan / chemistry*
  • Humans
  • Hyaluronic Acid / chemistry*
  • Molecular Structure
  • Skin
  • Wound Healing

Substances

  • Biopolymers
  • Hyaluronic Acid
  • Chitosan