Functionalization of Synthetic Bone Substitutes

André Busch; Marcus Jäger; Constantin Mayer; Andrea Sowislok

doi:10.3390/ijms22094412

Functionalization of Synthetic Bone Substitutes

Int J Mol Sci. 2021 Apr 23;22(9):4412. doi: 10.3390/ijms22094412.

Authors

André Busch^{1

2}, Marcus Jäger^{1

3}, Constantin Mayer¹, Andrea Sowislok²

Affiliations

¹ Department of Orthopedics, Trauma and Reconstructive Surgery, St. Marien Hospital Mülheim an der Ruhr, D-45468 Mülheim, Germany.
² Department of Orthopedics and Trauma Surgery, University Hospital Essen, University of Duisburg-Essen, D-45147 Essen, Germany.
³ Chair of Orthopedics and Trauma Surgery, University of Duisburg Essen, D-45147 Essen, Germany.

Abstract

Bone substitutes have been applied to treat osseous defects for a long time. To prevent implant related infection (IRI) and enhance bone healing functionalized biomaterials, antibiotics and osteoinductive substances have been introduced. This study gives an overview of the current available surface-coated bone substitutes and provides an outlook for future perspectives.

Keywords: BMP; antibiotics; implant related infections; tissue engineering.

Publication types

Review

MeSH terms

Animals
Bacterial Infections / drug therapy*
Bacterial Infections / microbiology
Biocompatible Materials / chemistry
Biocompatible Materials / therapeutic use
Bone Substitutes / chemistry*
Bone Substitutes / therapeutic use*
Bone and Bones / drug effects*
Humans

Substances

Biocompatible Materials
Bone Substitutes