Synthesis and Single Crystal Structures of N-Substituted Benzamides and Their Chemoselective Selenation/Reduction Derivatives

Guoxiong Hua; Cameron L Carpenter-Warren; David B Cordes; Alexandra M Z Slawin; J Derek Woollins

doi:10.3390/molecules26082367

Synthesis and Single Crystal Structures of N-Substituted Benzamides and Their Chemoselective Selenation/Reduction Derivatives

Molecules. 2021 Apr 19;26(8):2367. doi: 10.3390/molecules26082367.

Authors

Guoxiong Hua¹, Cameron L Carpenter-Warren¹, David B Cordes¹, Alexandra M Z Slawin¹, J Derek Woollins^{1

2}

Affiliations

¹ EaStCHEM School of Chemistry, University of St Andrews, St Andrews Fife KY16 9ST, UK.
² Department of Chemistry, Khalifa University, Abu Dhabi 127788, United Arab Emirates.

Abstract

A series of N-aryl-N-(2-oxo-2-arylethyl) benzamides and cinnamides has been prepared. The reaction of the benzamides with Woollins' reagent, a highly efficient chemoselective selenation/reduction reagent, gave the corresponding N-aryl-N-(arylenethyl) benzoselenoamides in good yields. Five representative single crystal X-ray structures are discussed.

Keywords: N-Substituted Benzamides; Woollins’ reagent; reduction reagent; selenation reagent; single crystal X-ray structures.