Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging

Int J Mol Sci. 2021 Apr 12;22(8):3974. doi: 10.3390/ijms22083974.

Abstract

Skin is the largest and most complex organ in the human body comprised of multiple layers with different types of cells. Different kinds of environmental stressors, for example, ultraviolet radiation (UVR), temperature, air pollutants, smoking, and diet, accelerate skin aging by stimulating inflammatory molecules. Skin aging caused by UVR is characterized by loss of elasticity, fine lines, wrinkles, reduced epidermal and dermal components, increased epidermal permeability, delayed wound healing, and approximately 90% of skin aging. These external factors can cause aging through reactive oxygen species (ROS)-mediated inflammation, as well as aged skin is a source of circulatory inflammatory molecules which accelerate skin aging and cause aging-related diseases. This review article focuses on the inflammatory pathways associated with UVR-mediated skin aging.

Keywords: inflammation; skin aging; ultraviolet radiation (UVR).

Publication types

  • Review

MeSH terms

  • Antioxidants / therapeutic use
  • Elasticity / drug effects
  • Humans
  • Inflammation / genetics*
  • Inflammation / pathology
  • Inflammation / prevention & control
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / radiation effects*
  • Skin / metabolism
  • Skin / pathology
  • Skin / radiation effects*
  • Skin Aging / genetics*
  • Skin Aging / pathology
  • Skin Aging / radiation effects
  • Ultraviolet Rays / adverse effects

Substances

  • Antioxidants
  • Reactive Oxygen Species