Recent Advances in PRRS Virus Receptors and the Targeting of Receptor-Ligand for Control

Chia-Ming Su; Raymond Robert Richard Rowland; Dongwan Yoo

doi:10.3390/vaccines9040354

Recent Advances in PRRS Virus Receptors and the Targeting of Receptor-Ligand for Control

Vaccines (Basel). 2021 Apr 7;9(4):354. doi: 10.3390/vaccines9040354.

Authors

Chia-Ming Su¹, Raymond Robert Richard Rowland¹, Dongwan Yoo¹

Affiliation

¹ Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.

Abstract

Cellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, CD163, a cysteine-rich scavenger receptor on macrophages, is the major receptor for PRRSV. This review discusses the recent advances and understanding of the entry of PRRSV into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor-ligand for the control of PRRS.

Keywords: CD163; PRRSV; porcine reproductive and respiratory syndrome; receptor.

Publication types

Review

Abstract

Publication types

Grants and funding