Engineered mutualistic consortia of microalgae and bacteria may be a means of assembling a novel combination of metabolic capabilities with potential biotechnological advantages. Microalgae are promising organisms for the sustainable production of metabolites of commercial interest, such as lipids, carbohydrates, pigments, and proteins. Several studies reveal that microalgae growth and cellular storage of these metabolites can be enhanced significantly by co-cultivation with growth-promoting bacteria. This review summarizes the state of the art of microalgae-bacteria consortia for the production of microalgal metabolites. We discuss the current knowledge on microalgae-bacteria mutualism and the mechanisms of bacteria to enhance microalgae metabolism. Furthermore, the potential routes for a microalgae-bacteria biorefinery are outlined in an attempt to overcome the economic failures and negative energy balances of the existing production processes.
Keywords: biorefinery; growth-promoting bacteria; metabolites; microalgae; mutualism.