Altered regional homogeneity and connectivity in cerebellum and visual-motor relevant cortex in Parkinson's disease with rapid eye movement sleep behavior disorder

Jinjing Liu; Guangying Shuai; Weidong Fang; Yingcheng Zhu; Huiyue Chen; Yuchan Wang; Qun Li; Yu Han; Dezhi Zou; Oumei Cheng

doi:10.1016/j.sleep.2021.03.041

Altered regional homogeneity and connectivity in cerebellum and visual-motor relevant cortex in Parkinson's disease with rapid eye movement sleep behavior disorder

Sleep Med. 2021 Jun:82:125-133. doi: 10.1016/j.sleep.2021.03.041. Epub 2021 Apr 9.

Authors

Affiliations

¹ Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
² Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
³ Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. Electronic address: chengoumei01@aliyun.com.

PMID: 33915428
DOI: 10.1016/j.sleep.2021.03.041

Abstract

Objective: Rapid eye movement sleep behavior disorder (RBD) frequently occurs in Parkinson's disease (PD), however, the exact pathophysiological mechanism underlying its occurrence is not clear. In this study, we explored whether there is abnormal spontaneous neuronal activities and connectivity maps in some brain areas under resting-state in PD patients with RBD.

Methods: We recruited 38 PD patients (19 PD with RBD and 19 PD without RBD), and 20 age- and gender-matched normal controls. We used resting-state functional magnetic resonance imaging (RS-fMRI) to analyze regional homogeneity (ReHo) and functional connectivity (FC), and further to reveal the neuronal activity in all subjects.

Results: Compared with the PD without RBD patients, the PD with RBD patients showed a significant increase in regional homogeneity in the left cerebellum, the right middle occipital region and the left middle temporal region, and decreased regional homogeneity in the left middle frontal region. The REM sleep behavioral disorders questionnaire scores were significantly positively correlated with the ReHo values of the left cerebellum. The functional connectivity analysis in which the four regions described above were used as regions of interest revealed increased functional activity between the left cerebellum and bilateral occipital regions, bilateral temporal regions and bilateral supplementary motor area.

Conclusion: The pathophysiological mechanism of PD with RBD may be related to abnormal spontaneous neuronal activity patterns with strong synchronization of cerebellar and visual-motor relevant cortex, and the increased connectivity of the cerebellum with the occipital and motor regions.

Keywords: Cerebellum; Functional connectivity (FC); Parkinson's disease (PD); Rapid eye movement sleep behavior disorder (RBD); Regional homogeneity (ReHo); Resting-state functional magnetic resonance imaging (RS-fMRI).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain
Cerebellum / diagnostic imaging
Humans
Magnetic Resonance Imaging
Motor Cortex*
Parkinson Disease* / complications
Parkinson Disease* / diagnostic imaging
REM Sleep Behavior Disorder* / diagnostic imaging