An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization

Dalton Trans. 2021 May 11;50(18):6071-6075. doi: 10.1039/d1dt00740h.

Abstract

Complex cis-[PtI2(NH3)(pic)] (1; pic = 2-methylpyridine), a diiodido analogue of clinically studied picoplatin (2), is unstable in solution, which is intriguingly connected with the release of its pic ligand. This observation complicates the biological testing of e.g. cytotoxicity in human cancer cells for 1.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Iodine / chemistry
  • Iodine / pharmacology*
  • Organoplatinum Compounds / chemistry
  • Organoplatinum Compounds / pharmacology*
  • Solutions
  • Thermodynamics

Substances

  • Antineoplastic Agents
  • Organoplatinum Compounds
  • Solutions
  • amminedichloro(2-methylpyridine)platinum(II)
  • Iodine