Abstract
Complex cis-[PtI2(NH3)(pic)] (1; pic = 2-methylpyridine), a diiodido analogue of clinically studied picoplatin (2), is unstable in solution, which is intriguingly connected with the release of its pic ligand. This observation complicates the biological testing of e.g. cytotoxicity in human cancer cells for 1.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Iodine / chemistry
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Iodine / pharmacology*
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Organoplatinum Compounds / chemistry
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Organoplatinum Compounds / pharmacology*
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Solutions
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Thermodynamics
Substances
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Antineoplastic Agents
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Organoplatinum Compounds
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Solutions
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amminedichloro(2-methylpyridine)platinum(II)
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Iodine