Mitochondria selective trackers for long-term imaging based on readily accessible neutral BODIPYs

Chem Commun (Camb). 2021 May 27;57(43):5318-5321. doi: 10.1039/d1cc00451d.

Abstract

We report the design of a new model based on a small neutral 8-aryl-3-formylBODIPY and its suitability to develop privileged highly bright and photostable fluorescent probes for selective and, more importantly, covalent staining of mitochondria.

MeSH terms

  • Benzyl Compounds / chemistry
  • Benzyl Compounds / metabolism
  • Boron Compounds / chemical synthesis
  • Boron Compounds / chemistry*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Humans
  • Mitochondria / chemistry*
  • Mitochondria / metabolism
  • Molecular Structure
  • Optical Imaging*
  • PC-3 Cells
  • Photochemical Processes

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Benzyl Compounds
  • Boron Compounds
  • Fluorescent Dyes
  • benzyl chloride