Review of 10,11-Dehydrocurvularin: Synthesis, Structural Diversity, Bioactivities and Mechanisms

Mini Rev Med Chem. 2022;22(6):836-847. doi: 10.2174/1389557521666210428132256.

Abstract

10,11-Dehydrocurvularin is a natural benzenediol lactone (BDL) with a 12-membered macrolide fused to a resorcinol ring produced as a secondary metabolite by many fungi. In this review, we summarized the pieces of literature regarding biosynthesis, chemical synthesis, biological activities, and assumed work mechanisms of 10,11-dehydrocurvularin, which presented a potential for agricultural and pharmaceutical uses.

Keywords: 10; 11-Dehydrocurvularin; antitumor; benzenediol lactone (BDL); bioactivity; structure-activity-relationship; target.

Publication types

  • Review

MeSH terms

  • Fungi / metabolism
  • Lactones* / chemistry
  • Macrolides
  • Zearalenone* / analogs & derivatives
  • Zearalenone* / pharmacology

Substances

  • Lactones
  • Macrolides
  • Zearalenone
  • curvularin