The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway

Chun Tang; Xuehui Wang; Changle Ji; Wenfang Zheng; Yunhe Yu; Xiaochong Deng; Xiqian Zhou; Lin Fang

doi:10.3389/fonc.2021.645682

The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway

Front Oncol. 2021 Apr 12:11:645682. doi: 10.3389/fonc.2021.645682. eCollection 2021.

Authors

Chun Tang^{1

2}, Xuehui Wang^{1

3}, Changle Ji³, Wenfang Zheng³, Yunhe Yu³, Xiaochong Deng³, Xiqian Zhou³, Lin Fang^{1

3}

Affiliations

¹ Clinical Medical College of Shanghai Tenth People's Hospital, Nanjing Medical University, Nanjing, China.
² Department of Thyroid and Breast Surgery, Taizhou Fourth People's Hospital, Taizhou, China.
³ Department of Thyroid and Breast Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Abstract

In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC in vitro and in vivo, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 could directly target Wnt7b, thereby regulating Wnt/β-catenin signaling pathway in BC. In conclusion, miR-640/Wnt7b suppresses BC cells tumorigenesis via Wnt/β-catenin signaling pathway, which might be novel targets for BC targeted therapy.

Keywords: Wnt/β-catenin pathway; Wnt7b; breast cancer; miR-640; β-catenin.