A Preliminary Investigation on Plasma Cell Adhesion Molecules Levels by Protein Microarray Technology in Major Depressive Disorder

Wanying Liu; Yanqun Zheng; Fuxu Zhang; Mo Zhu; Qian Guo; Hua Xu; Caiping Liu; Haiying Chen; Xiaoliang Wang; Yao Hu; Tianhong Zhang; Zhiguang Lin; Chen Zhang; Guanjun Li; Kaida Jiang; Xiaohua Liu

doi:10.3389/fpsyt.2021.627469

A Preliminary Investigation on Plasma Cell Adhesion Molecules Levels by Protein Microarray Technology in Major Depressive Disorder

Front Psychiatry. 2021 Apr 12:12:627469. doi: 10.3389/fpsyt.2021.627469. eCollection 2021.

Authors

Wanying Liu¹, Yanqun Zheng¹, Fuxu Zhang¹, Mo Zhu¹, Qian Guo¹, Hua Xu¹, Caiping Liu¹, Haiying Chen¹, Xiaoliang Wang¹, Yao Hu¹, Tianhong Zhang^{1

2}, Zhiguang Lin², Chen Zhang², Guanjun Li¹, Kaida Jiang¹, Xiaohua Liu^{1

2}

Affiliations

¹ Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Objectives: Major depressive disorder (MDD) is a serious mental disorder, and there is a great difficulty to diagnose and treat. Hitherto, relatively few studies have explored the correlation between the levels of plasma cell adhesion molecules and MDD. Methods: Thirty outpatients with acute episodes of MDD in Shanghai Mental Health Center and 34 healthy volunteers from the community were recruited as subjects. Protein microarray technology was applied to compared the differences in plasma levels of 17 kinds of adhesion molecular proteins between the two groups. Meanwhile, the diagnostic value of different proteins in depression was discussed by using the receiver operating characteristic curve. Results: The levels of Carcinoembryonic Antigen Related Cell Adhesion Molecule-1(CEACAM-1) and Neural Cell Adhesion Molecule (NrCAM) in MDD patients were significantly higher than those in healthy controls (P < 0.05). The area under ROC curve of CEACAM-1 combined with NrCAM was 0.723, with the sensitivity 0.800 and the specificity 0.676. Conclusion: The plasma levels of CEACAM-1 and NrCAM were significantly up-regulated in MDD, and their combined application was of potential diagnostic value, deserving to expand the sample size for further verification.

Keywords: cell adhesion molecule; diagnosis; major depressive disorder; plasma marker; protein microarray.