Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study

Ming Zhong; Yi-Ru Yang; Yong-Ze Zhang; Sun-Jie Yan

doi:10.2147/DMSO.S303096

Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study

Diabetes Metab Syndr Obes. 2021 Apr 22:14:1763-1772. doi: 10.2147/DMSO.S303096. eCollection 2021.

Authors

Ming Zhong^{1

2

3}, Yi-Ru Yang⁴, Yong-Ze Zhang^{1

2

3}, Sun-Jie Yan^{1

2

3}

Affiliations

¹ Department of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People's Republic of China.
² Fujian Diabetes Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People's Republic of China.
³ Metabolic Diseases Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People's Republic of China.
⁴ Department of Ultrasound, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, People's Republic of China.

Abstract

Purpose: This study aimed to assess association between change in urine albumin-to-creatinine ratio (UACR) and the risk of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.

Patients and methods: A retrospective study was performed, which included 185 individuals with type 2 diabetes. At baseline, and at two-year follow-up, we collected basic data, recorded symptoms and signs of DPN, measured biochemical indicators, composite motor nerve conduction velocity (composite MCV), and composite sensory nerve conduction velocity (composite SCV).

Results: Changes of composite SCV, MCV and TCSS among different changes in UACR in patients without DPN and with DPN were not significantly different. An increase in UACR ≥30% (OR 3.059, 95%; CI: 1.012-9.249) suggested a risk for new-onset DPN. Based on ROC curve analysis, the areas under the curve were 0.654 ± 0.066 for change of UACR levels in non-DPN patients.

Conclusion: Change in UACR and NCV was not related in patients without DPN and with DPN; change in UACR ≥30% suggested a risk for new-onset DPN.

Keywords: diabetic peripheral neuropathy; nerve conduction velocity; type 2 diabetes; urine albumin-to-creatinine ratio.

Grants and funding

This study was supported by Startup Fund for scientific research, Fujian Medical University (Grant number: 2018QH1077) and the Central Government Special Funds for Local Science and Technology Development (2018L3007).