Palladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1 H)-ones

Jian-Li Liu; Ren-Rui Xu; Wei Wang; Xinxin Qi; Xiao-Feng Wu

doi:10.1039/d1ob00298h

Palladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1 H)-ones

Org Biomol Chem. 2021 Apr 28;19(16):3584-3588. doi: 10.1039/d1ob00298h.

Authors

Jian-Li Liu¹, Ren-Rui Xu¹, Wei Wang¹, Xinxin Qi¹, Xiao-Feng Wu²

Affiliations

¹ Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China. xinxinqi@zstu.edu.cn.
² Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023, Dalian, Liaoning, China. xwu2020@dicp.ac.cn and Leibniz-Institut für Katalyse e.V. an der, Institution Universität Rostock, Albert-Einstein-Straße 29a, Rostock 18059, Germany. xiao-feng.wu@catalysis.de.

PMID: 33908566
DOI: 10.1039/d1ob00298h

Abstract

An efficient carbonylative procedure for the synthesis of 3-arylquinoin-2(1H)-ones has been established. Through a palladium-catalyzed aminocarbonylation of benzyl chlorides with anthranils, a variety of 3-arylquinoin-2(1H)-one products were obtained in moderate to excellent yields with good functional group tolerance.