A PDA-DTC/Cu-MnO2 nanoplatform for MR imaging and multi-therapy for triple-negative breast cancer treatment

Chem Commun (Camb). 2021 Apr 27;57(34):4158-4161. doi: 10.1039/d1cc00987g.

Abstract

Herein, a multi-functional nanoplatform (PDA-DTC/Cu-MnO2) was established, which has been employed for MR imaging-guided multi-therapy (CDT, PTT and chemotherapy) for cancer treatment. The in vitro and in vivo results confirmed that the biocompatible nanoplatform could significantly induce tumor cell death and inhibit tumor growth.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Copper / chemistry
  • Copper / pharmacology
  • Ditiocarb / chemistry
  • Ditiocarb / pharmacology
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • Indoles / chemistry
  • Indoles / pharmacology
  • Magnetic Resonance Imaging*
  • Mammary Neoplasms, Experimental / diagnostic imaging
  • Mammary Neoplasms, Experimental / drug therapy
  • Manganese Compounds / chemistry
  • Manganese Compounds / pharmacology
  • Mice
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Optical Imaging
  • Oxides / chemistry
  • Oxides / pharmacology
  • Particle Size
  • Polymers / chemistry
  • Polymers / pharmacology
  • Triple Negative Breast Neoplasms / diagnostic imaging*
  • Triple Negative Breast Neoplasms / drug therapy*

Substances

  • Antineoplastic Agents
  • Indoles
  • Manganese Compounds
  • Oxides
  • Polymers
  • polydopamine
  • Copper
  • Ditiocarb
  • manganese dioxide