Abstract
A porphysome-based photodynamic O2 economizer (P-PAT) is prepared for hypoxic tumor therapy. The self-assembled porphyrin bilayers of P-PAT possess high loading capacity to atovaquone (ATO) (nearly 70%), which could restrain mitochondrial respiration to relieve hypoxia and enhance photodynamic therapy.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Atovaquone / chemistry
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Atovaquone / pharmacology
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Cell Hypoxia / drug effects*
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Cell Line, Tumor
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Female
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Mice
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Mitochondria / drug effects*
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Mitochondria / metabolism
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Molecular Structure
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Oxygen / metabolism*
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Photochemotherapy*
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Porphyrins / chemistry
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Porphyrins / pharmacology*
Substances
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Antineoplastic Agents
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Porphyrins
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Oxygen
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Atovaquone