The Past, Present, and Future of PrEP implementation Among People Who Use Drugs

Katie B Biello; Matthew J Mimiaga; Pablo K Valente; Nimish Saxena; Angela R Bazzi

doi:10.1007/s11904-021-00556-z

The Past, Present, and Future of PrEP implementation Among People Who Use Drugs

Curr HIV/AIDS Rep. 2021 Aug;18(4):328-338. doi: 10.1007/s11904-021-00556-z. Epub 2021 Apr 27.

Authors

Katie B Biello^{1

2

3

4}, Matthew J Mimiaga^{5

6

7

8}, Pablo K Valente^{9

10}, Nimish Saxena⁵, Angela R Bazzi^{11

12}

Affiliations

¹ Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA. katie_biello@brown.edu.
² Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. katie_biello@brown.edu.
³ Center for Health Promotion and Health Equity, Brown University, Providence, RI, USA. katie_biello@brown.edu.
⁴ The Fenway Institute, Fenway Health, Boston, MA, USA. katie_biello@brown.edu.
⁵ The Fenway Institute, Fenway Health, Boston, MA, USA.
⁶ Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
⁷ Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁸ Center for LGBTQ Advocacy, Research, and Health, University of California Los Angeles, Los Angeles, CA, USA.
⁹ Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA.
¹⁰ Center for Health Promotion and Health Equity, Brown University, Providence, RI, USA.
¹¹ Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA.
¹² Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USA.

Abstract

Purpose of review: Recent HIV outbreaks among people who use drugs (PWUD) necessitate additional HIV prevention tools. Pre-exposure prophylaxis (PrEP) is highly efficacious yet uptake among PWUD remains exceedingly low. To address multilevel, complex barriers to PrEP use among PWUD, a range of intervention strategies are needed.

Recent findings: The literature on interventions to optimize PrEP use among PWUD is nascent, comprising small pilots and demonstration projects in early phases of intervention development. Initial studies suggest that structural, healthcare, interpersonal, and individual-level interventions can improve PrEP use for PWUD, and a number of efficacy trials are underway. Future studies are needed to optimize the use of new PrEP modalities (e.g., injectable PrEP), simultaneously target multilevel challenges to PrEP use, and evaluate the integration of PrEP into other service settings and substance use treatment modalities.

Keywords: HIV; Injection drug use; Opioids; PrEP; Stimulants; Substance use.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Anti-HIV Agents* / therapeutic use
HIV Infections* / drug therapy
HIV Infections* / prevention & control
Humans
Pharmaceutical Preparations*
Pre-Exposure Prophylaxis*
Safe Sex

Substances

Anti-HIV Agents
Pharmaceutical Preparations

Abstract

Publication types

MeSH terms

Substances

Grants and funding