One-Year Evolution of Symptoms and Health Status of the COPD Multi-Dimensional Phenotypes: Results from the Follow-Up of the STORICO Observational Study

Raffaele Antonelli Incalzi; Francesco Blasi; Nicola Scichilone; Alessandro Zullo; Lucia Simoni; Giorgio Walter Canonica; STORICO study group

doi:10.2147/COPD.S289697

One-Year Evolution of Symptoms and Health Status of the COPD Multi-Dimensional Phenotypes: Results from the Follow-Up of the STORICO Observational Study

Int J Chron Obstruct Pulmon Dis. 2021 Apr 20:16:1007-1020. doi: 10.2147/COPD.S289697. eCollection 2021.

Authors

Raffaele Antonelli Incalzi¹, Francesco Blasi^{2

3}, Nicola Scichilone⁴, Alessandro Zullo⁵, Lucia Simoni⁵, Giorgio Walter Canonica⁶; STORICO study group

Affiliations

¹ Internal Medicine and Geriatrics Department Biomedical Campus University of Rome, Rome, Italy.
² Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
³ Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
⁴ DIBIMIS, University of Palermo, Palermo, Italy.
⁵ Medineos Observational Research, Modena, Italy.
⁶ Personalized Medicine Asthma & Allergy Clinic, Humanitas University, Humanitas & Research Hospital-IRCCS, Rozzano (Milan), Italy.

Abstract

Aim: Describing the 1-year evolution of symptoms and health status in COPD patients enrolled in the STORICO study (observational study on characterization of 24-h symptoms in patients with COPD) classified in multidimensional phenotypes (m-phenotypes).

Methods: In our previous study, we performed an exploratory factor analysis to identify clinical and pathophysiological variables having the greatest classificatory properties, followed by a cluster analysis to group patients into m-phenotypes (mild COPD (MC), mild emphysematous (ME), severe bronchitic (SB), severe emphysematous (SE), and severe mixed COPD (SMC)). COPD symptoms were recorded at baseline, 6-, and 12-month follow-up and their evolution was described as frequency of patients with always present, always absent, arising', 'no more present symptoms. QoL and quality of sleep were evaluated using the SGRQ and CASIS questionnaires, respectively.

Results: We analyzed 379 subjects (144 MC, 71 ME, 96 SB, 14 SE, 54 SMC). M-phenotypes were stable over time in terms of presence of symptoms and health status with selected differences in evolution of symptoms in mild vs severe m-phenotypes. Indeed, 28.1% SB, 50.0% SE and 24.1% SMC vs 0.7% MC and 5.6% ME with night-time symptoms at baseline had no more symptoms at 6-month (p-value night-time symptom evolution MC vs SB, SE, SMC and ME vs SB, SE, SMC <0.0001). All m-phenotypes improved in quality of sleep, more markedly the severe than the mild ones (p-values CASIS score change between baseline and 6- or 12-month in MC, ME vs SB, SE, SMC <0.0001). QoL did not change during observation, irrespectively of m-phenotype.

Conclusion: Over 1 year, severe m-phenotypes showed an improvement in night-time symptoms and quality of sleep, but not QoL. Being stable over time, m-phenotypes seem worthy of testing for classificatory and prognostic purposes.

Keywords: cohort study; evolution; phenotype; quality of life; quality of sleep; real world.

Publication types

Observational Study

MeSH terms

Follow-Up Studies
Health Status
Humans
Phenotype
Pulmonary Disease, Chronic Obstructive* / diagnosis
Pulmonary Disease, Chronic Obstructive* / epidemiology
Pulmonary Disease, Chronic Obstructive* / therapy
Quality of Life*
Surveys and Questionnaires

Grants and funding

The study was supported by a grant from Laboratori Guidotti and Malesci, Italy. The funding sources were not involved in study design, in the collection, analysis and interpretation of data, and in the preparation of the article for publication.